Darier sign: Definition, Uses, and Clinical Overview
Darier sign is a skin finding where rubbing or scratching a lesion makes it become raised, red, and itchy (a “wheal-and-flare” reaction). It is most commonly used in clinical examinations to support a diagnosis of cutaneous mastocytosis (mast cell–related skin lesions). It is a physical exam sign, not a cosmetic procedure or treatment. It may be relevant in both reconstructive and aesthetic settings because it can affect how skin lesions behave during evaluation, surgery planning, or post-procedure monitoring.